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KMID : 1134820110400111556
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Journal of the Korean Society of Food Science and Nutrition
2011 Volume.40 No. 11 p.1556 ~ p.1561
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Effect of Hizikia fusiforme Extracts on Antioxidant Enzyme Activity and Vitamin E Concentration in Rats
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Kim Hyang-Suk
Choi Eun-Ok
Park Cheol
Choi Young-Hyun
Hyun Sook-Kyung
Hwang Hye-Jin
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Abstract
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The purpose of this study was to investigate antioxidant enzyme activity and vitamin E concentrationin in Sprague-Dawley rat after being fed various extracts of Hizikia fusiforme. There were six experimental groups: control group (C), H. fusiforme ethanol extract group (EtOH), H. fusiforme dichloromethane fraction group (CH2Cl2), H. fusiforme ethylacetate fraction group (EtOAc), H. fusiforme butanol fraction group (n-BuOH), H.fusiforme water fraction group (H2O). H. fusiforme extracts (400 mg/kg B.W) were orally administrated to the rats every day for 4 weeks. The activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), and concentrations of malondialdehyde (MDA) and vitamin E in the liver and blood were measured.The activity of SOD in the liver was significantly higher in the CH2Cl2 and H2O groups (p<0.05) than in the control and other extract groups. The SOD activity in serum increased significantly in all H. fusiforme groups (p<0.05) compared to the control group and it was also significantly higher in the EtOH and H2O groups (p<0.05) than in other extract groups. The serum catalase activity increased significantly in the n-BuOH group (p<0.05) compared to the control and other extract groups. The plasma MDA concentration decreased significantly in the n-BuOH and H2O group (p<0.05) compared to the control group. Serum concentration of α-tocopherol showed no significant differences in most of the experimental groups, but it was significantly higher in the EtOAc group (p<0.05). The α-tocopherol concentrations in the liver showed a significant increase in the CH2Cl2 and H2O groups (p<0.05) compared to the control and other extract groups. The liver γ-tocopherol concentrations in H. fusiforme extract groups showed a tendency to increase compared to the control group and it was significantly higher in the H2O group (p<0.05) than in other extract groups. These results suggest that supplementation of water extracts of H. fusiforme extract could be effective in improving the antioxidant system.
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KEYWORD
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Hizikia fusiforme, SOD, catalase, GSH-Px, MDA, α-tocopherol, γ-tocopherol
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